Studies of the Metabolic Activity of Leukocytes from Patients with a Genetic Abnormality of Phagocytic Function*

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Studies of the metabolic activity of leukocytes from patients with a genetic abnormality of phagocytic function.

Polymorphonuclear leukocytes from patients with chronic granulomatous disease respond to the phagocytosis of latex particles with normal increments in glucose consumption, lactate production, Krebs' cycle activity, and lipid turnover. The leukocytes of these patients fail to show normal increments in respiration, direct oxidation of glucose, and hydrogen peroxide formation during particle uptak...

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ژورنال

عنوان ژورنال: Journal of Clinical Investigation

سال: 1967

ISSN: 0021-9738

DOI: 10.1172/jci105634